Comparison of two different doses of hyperbaric bupivacaine for intracavitary radiotherapy in patients with carcinoma cervix ? A randomized control trial

Background: Subarachnoid block has been used for intracavitary radiotherapy (ICRT) for carcinoma cervix, but the literature on the appropriate dose of local anesthetic required to achieve the desired effect is lacking. We compared two different intrathecal doses of 0.5% hyperbaric bupivacaine (1.2 and 1.5 mL) for providing optimal surgical conditions and readiness to discharge in patients undergoing ICRT for carcinoma cervix. Materials and Methods: This prospective double?blind study was done in 80 patients undergoing ICRT. The patients were randomized into two groups (Groups I and II) to receive 1.2 and 1.5 mL of intrathecal hyperbaric bupivacaine, respectively, for ICRT. The level of sensory achieved, the patient satisfaction score, radiation oncologist score, time to L5 regression, and time to motor recovery (walking unaided) were assessed. Statistical Analysis Used: The data were analyzed using SPSS 20 for Windows (IBM, Chicago, IL, USA). Results: The time taken for the block to regress to L5 (Group I: 134.6 � 32.4 minutes vs. Group II: 143.2 � 43.0 minutes, P = 0.31) were comparable. However, the mean time for walking unaided (Group I: 220.87 � 47.12 minutes versus Group II: 247.00 � 49.83 minutes, P = 0.032) after the subarachnoid block was significantly less in Group I. The patient satisfaction with the procedure and overall satisfaction of the radiation oncologists regarding the operating condition were comparable in both the groups. Conclusions: Hence, a 1.2 mL dose of intrathecal hyperbaric bupivacaine for ICRT provides optimal surgical conditions with hemodynamic stability and ensures the early discharge of the patient.

A surgical management of articular disc injury in temporomandibular Joint: A compiled case series of two cases with articular disc tear managed with surgical intervention

Articular disc injury in the temporomandibular joint (TMJ) can lead to significant pain and limited jaw movement. We present two cases in this case series of articular disc injuries in the TMJ and elaborate on their etiology, clinical presentation, diagnostic modalities, and treatment provided with follow-up reviews. Case 1 involved a 50-year-old female with a history of pain and clicking in the left TMJ for 10 years, wherein imaging studies revealed a discal tear. Case 2 involved a patient who presented with trauma and was diagnosed with a displaced disc with a disc tear when the patient was screened for mandibular fractures. The patients underwent surgical intervention, and the disc tear was repaired, following which both showed marked improvement. Our cases highlight the importance of early diagnosis and necessary surgical management of articular disc injury in the TMJ for better clinical outcomes.

Cotard’s syndrome in the postoperative period following head and neck cancer surgery – A case report

Major head and neck surgery is a known factor for postoperative delirium; however, Cotard’s syndrome (CS) has been rarely reported following head and neck surgery. We report a case of a 51?year?old man who underwent surgery for carcinoma right buccal mucosa and developed agitation and nihilistic delusion after extubation. The patient had a preexisting psychiatric history which is often reported as a risk factor for CS. Of interest, though is that this condition subsided as quickly as it emerged with only supportive counselling and brief pharmacotherapy.

Ginseng used for bone tissue scaffold

The scaffold based tissue engineering materialized for bone tissue therapy. Gelatin-glutaraldehyde cross linked scaffold was prepared by solvent casting -porogen leaching method. It was characterized by FTIR and SEM microphotograph analysis. Absence of peak at waves no. 1625 cm?1 in ATR-FTIR indicated formation of cross-linking. FE-SEM micrograph showed honeycomb pad like structure with high porosity. Methanolic extract of Withania somnifera (Ashwagandha) root extract induced MC3T3 E1 osteoblast cell adhesion and proliferation on porous gelatin scaffold. GC-MS analysis pointed out presence of 4-amino- 2-ethyl-3-methylquinoline, an active phyto-chemicals having tissue regeneration potential. High anti-oxidant capacity down regulates cell death mechanism by scavenging free radical. The biocompatible gelatin scaffold has RGD moiety that attune the MC3T3 E1 osteoblast cell adhesion. Withania somnifera root extract may boost up cell proliferation on scaffold. Therefore treatment with Withania somnifera root extract may be the new approaches for designing bone tissue scaffold for bone tissue therapy.

Short- and long-term cardiovascular outcomes in insulin-treated versus non-insulin-treated diabetes mellitus patients after percutaneous coronary intervention: A systematic review and meta-analysis

Aims: This study aims to assess differences in severity of short-term (<1 year) and long-term (_x005F_x0001_1 year) adverse CV outcomes after PCI in insulin-treated vs. non-insulin-treated diabetes mellitus (DM) patients. Methods: A systematic search on Pubmed and Embase led to the incorporation of 29 studies that compared post-percutaneous coronary interventional outcomes in insulin-treated and non-insulintreated diabetes mellitus. Diabetes mellitus (type 2) was defined as fasting blood glucose (FBG) level of >7.0 mmol/L or with an oral glucose tolerance test (OGTT) level of >11.1 mmol/L at least on two separate occasions. Adverse CV outcomes were assessed in insulin-treated and non-insulin-treated DM after the PCI procedure considered for the analyses were mortality, MACE, TLR, TVR, MI, stent thrombosis, target lesion failure (TLF), and need for-post PCI CABG. Data were pooled and analyzed using Review Manager 5.3, and risk ratios (RR) with respective 95% confidence intervals (CI) were calculated.The statistical analyses were carried out by Review Manager v.5.3, and the data were pooled using a random-effects model. Risk ratios (RRs) with 95% confidence intervals (CI) were reported along with forest plots. The chi-square test was performed to assess for differences between the subgroups. Heterogeneity across studies was evaluated using Higgins I2 statistics. Visual inspection of the funnel plot and Begg's regression test were used to assess publication bias. Results: A total of 40,527 patients (11742 in the Insulin-treated diabetes mellitus group and 28785 in the non-insulin-treated DM group) who underwent PCI were included. The pooled analysis of short-term follow up outcomes preceding PCI demonstrated a significantly higher risk of mortality (RR ¼ 1.75 [1.24,2.47]; p ¼ 0.002), MI (RR ¼ 1.81[1.14,2.87]; p ¼ 0.01], stent thrombosis (RR ¼ 1.63[1.13, 2.35]; p ¼ 0.009) and target lesion revascularization (TLR) (RR ¼ 1.29[1.02,1.63]; p ¼ 0.03) in insulin-treated DM patients. Similarly, analysis of long-term follow-up studies depicted a significantly higher risk mortality (RR ¼ 1.55 [1.22, 1.97]; p ¼ 0.0003), MI (RR ¼ 1.63 [1.35, 1.97]; p¼<0.00001), MACE (R ¼ 1.47 [1.31, 1.65]; p¼<0.00001), stent thrombosis (RR ¼ 1.54 [1.19,1.99]; p ¼ 0.001), TLR (RR ¼ 1.40 [1.18, 1.66]; p ¼ 0.0001), target vessel revascularization (TVR) (RR ¼ 1.35 [1.11, 1.64]; p ¼ 0.003) in insulin-treated DM group after PCI versus non-insulin-treated DM patients. Conclusion: Despite a tremendous technical success rate of multi-vessel stenting, people living with diabetes who were being treated with insulin had higher long-term, and short-term mortality rates, MI, TLR, TVR, and stroke compared to people living with diabetes who were being treated with means other than insulin and are more prone to detrimental cardiovascular outcomes.

Compassionate and standard operating procedure-based counseling and practice are essential in high-risk infantile anesthesia and managing death in eye surgery

Physicians have to play the role of a team leader and counselor and take written informed consent for high?risk surgeries in many cases. This is the first step toward initiating a mutually trustworthy relationship with the patient and family. The situation is more sensitive when vulnerable patients like small premature babies or the elderly are under consideration. In the event of a death, leadership and processes in place become extremely critical. We share our experience and practice pattern during this process, especially suited to India, but the broad principles would apply to most human situations. Hopefully, some of these can be incorporated into the existing training curriculum for team building and the art of effective physician?patient communication that should be intricately woven into the curriculum for the Science of Ophthalmic care.

Zika virus vertical transmission in mosquitoes A less understood mechanism

Zika virus disease is a great concern in different parts of the world, and it has become a Public Health Emergency of International Concern. The global pandemic of ZIKV in 2015 prompted concern among scientific community. Zika is a flavivirus of the family Flaviviridae transmitted by mosquitoes. Natural vertical transmission is an ecological strategy that arboviruses adopt to ensure their survival inside the mosquito vector during harsh conditions or interepidemic periods when horizontal transmission is difficult. ZIKV is vertically transmitted from infected females to its offspring. This review has concluded various studies regarding the vertical transmission ability of different mosquito species for ZIKV. Previously Aedes aegypti was considered to be a major vector, however Aedes albopictus and Culex quinquifasciatus are discovered to have the similar vertical transmission potential. Different studies shown that natural vertical transmission has been detected in mosquito species which are not implicated as possible vectors. It leads to the possibility that many other mosquito species may be potential ZIKV vectors.

Understanding pelvic floor in women

Change from quadruped to erect posture has resulted in changes in the human pelvis. This has resulted in pelvis supporting the abdominal viscera. The bony pelvis is deficient on inferior aspect. Muscles covered by fascia on superior and inferior aspect. A good knowledge of pelvic floor is very basic and mandatory for any gynecologist as pelvic floor is crucial to support the pelvic organs and is required to maintain urinary and fecal continence.

Complete androgenin sensitivity syndrome presenting with primary amenorrhoea and inguinal mass: a case report

Androgen insensitivity syndrome (AIS), also known as testicular feminization, an X-linked recessive disorder comprises a wide range of phenotypes that are caused by various types of mutations in the androgen receptor gene. AIs can be classified as complete, partial, or mild based on the phenotypic presentation. The clinical findings include a female type of external genitalia, 46-XY karyotype, absence of Mullerian structures, presence of Wolffian structures to various degree, and normal to high testosterone and gonadotropin levels. We report this case as an interesting and rare syndrome. The patient is a 15-year-old phenotypic female who presented with primary amenorrhea and normal-appearing external genitalia. Orchidectomy was done after proper counselling and proper psychological support was given to her.

Prevalence of Diabetes and Associated Conditions in Women Coming for Delivery in a Tertiary Care Centre of Kumaon Region of Uttarakhand

Introdution: Diabetes in pregnancy either gestational or type1 or 2 is associated with morbidity for both the mother andfetus. It can lead to a lot of complications during antenatal,peripartum and postpartum period. Increased rate of LSCS,macrosomic fetus, difficulties during delivery (e.g. obstructedlabour, shoulder dystocia), congenital anomalies in the baby,stillbirth are very frequently associated with diabetes. ThisStudy was conducted to analyze the prevalence of diabetes(either Gestational or Pre-Gestational) and associatedconditions and draw a comparative evaluation in womencoming for delivery in the labour room of Govt. Medicalcollege, Haldwani , Uttarakhand.Material and methods: All the women who came fordelivery during the period from January 2017 to December2018 were tested for blood sugar regardless of whether theyare follow up patients or coming for the first time and alsoregardless of their antenatal history. After detailed history andexamination GCT with 75gm glucose was done. Dependingon the 2-hour glucose level and history, diagnosis of GDM orPre- Gestational diabetes were made.Result: During the study period total 8228 deliveries occurredin the labour room of Govt. Medical college, Haldwani,Uttarakhand. Of all these women 24(0.3%) were diagnosedwith GDM or DM by the history and tests conducted at thetime of admission. Of the 24 patients of diabetes 4(16.7%)were associated with Pregnancy induced hypertension, 6(25%)were associated with hypothyroidism and 10(41.7%) had noassociated condition. 9(36.7%) patients of the 24 deliveredbefore 36 week of gestational age and 15(73.7%) delivered atgestational age of more than 36 week. The mode of deliverywas LSCS in 19(79.16%) patients of the total 24 patients.Conclusion: Any form of diabetes either Gestational orPre-Gestational is a major cause of increased morbidity andmortality in pregnancy for both mother and fetus. Diabetes candevelop any time during pregnancy and so there are chance ofmissing on the diagnosis of diabetes by mere one time testingof blood sugar. So it is very necessary to keep repeating thesugar testing (glucose challange test) in a pregnant women at asignificant time interval. Even in women coming for deliveryirrespective of the history a blood sugar testing should be donenot only for diagnosis, but also for assessing the degree ofinsulin resistance.

Evaluation of efficacy of an ayurvedic mouthwash on dental plaque and gingivitis: a double blinded parallel randomized controlled study

Introduction: Due to inherent limitations of chlorhexidine, search for an effective and potentially safe anti-plaque agent has led to emergence of alternative products. Aim: To evaluate and compare the effects of Oral Pal Plus mouth rinse and chlorhexidine on dental plaque and gingivitis. Materials and Methods: The present study was randomized parallel group controlled trial. A group of 90 healthy subjects in the age group of 18-21 yrs received complete supragingival scaling at baseline and study variables viz, Plaque index and Gingival index were recorded. Subjects were then randomly divided into three groups (30 in each group) and were randomly intervened with three different mouthwashes. ie, Chlorhexidine, Oral Pal Plus and normal saline. Variables were again recorded on the 7th day 14th day after use of mouthwashes and data obtained was subjected to statistical analysis. Results: There was statistically significant reduction in plaque and gingival scores from baseline to 14 days in both the groups A & B. Conclusion: Chlorhexidine (0.2%) and Oral Pal Plus mouthwash showed significantly reduction in plaque scores and gingival scores whereas no improvement was seen in Group C using normal saline over 14 days. (AU)

Analysis of risk factors contributing to road traffic accidents in a tertiary care hospital. A hospital based cross-sectional study / 中华创伤杂志(英文版)

PURPOSE@#Road traffic accidents (RTAs) are a public health issue and cost a lot to individuals, families, communities and nations. Trauma care systems in India are at a nascent stage of development. There is gross disparity between trauma services available in various parts of the country. Rural area in India has inefficient services for trauma care, due to the varied topography, financial constraints, and lack of appropriate health infrastructure. The present study is to study the trends of occurrence of RTA cases by month, week and time of accident occurrence as well as to research the types of vehicle involved in accidents and other various risk factors related to them.@*METHODS@#During 1st January 2017 to 31st December 2017, a hospital-based and cross-sectional study of RTA victims was conducted. The patients were admitted in emergency department of Uttar Pradesh University of Medical Sciences, Saifai, Etawah, when stabilized, they were shifted to the orthopaedics and surgery ward.@*RESULTS@#In the study, 654 road accident victims were included, of which the majority were males (77.5%) and the most of them belonged to rural (67%). RTA victims according to the month of occurrence majority were found in January (12.5%) and evening was time of a day with maximum accidents (32.1%). Mortality cases of RTA victims based on type of road user and it shows decreasing trend of mortality of motorcyclists (54.2%) followed by pedestrian (25.1%).@*CONCLUSION@#There should be control over people driving vehicles under the influence of alcohol and drivers over-speeding and rash driving on urban roads as well as rural village roads.

Non Hodgkin’s Lymphoma Misdiagnosed As Tuberculosis: A Case Report

Non-Hodgkin’s Lymphoma is a heterogeneous group of malignancies characterized by an abnormal clonal proliferation of T-cells, B-cells or both. Sometimes, tuberculosis and lymphoma presentation can share common symptoms and features. A 37-year-old male patient was admitted in the hospital with complains of shortness of breath associated with cough, loss of appetite, generalized weakness and weight loss since two months. There were no palpable peripheral lymph nodes present anywhere in the body. The patient had no personal or family history of tuberculosis. The chest X-ray showed bilateral mild pleural effusion with confluent radio opacities in both lung fields. Pleural fluid biochemistry showed increased Adenosine deaminase level with increased protein and low sugar. Antitubercular drugs were started after initial diagnosis of tuberculosis. After non improvement in symptoms fine needle aspiration cytology (FNAC) was done from spleen which showed finding suggestive of non- hodgkins lymphoma

Human Immunodeficiency Virus and Human papillomavirus in Immunopathology of Cervical Cancer

The field of cancer immunobiology has been fast expanding.The realms of cervical cancer and immunodeficiency interactingat the molecular level has been actively investigated. The roleof the Human papillomavirus and developement of cervicalcancer admist a background of immunodeficiency is reviewedfor the novelty of the interaction between the HPV inducedoncogenesis and the host cellular responses in HIV positivewomen.The review aims to revisit the subject and generateinterest and research on HPV induced oncogenesis with anultimate aim to prevent cervical cancer. Greater understandingof the molecular pathways that underlie progression of highgrade IN to invasive cancer would be of great importancein the identification of the genetic markers that are able toidentify the women who have a high risk of progression tocancer, and therefore in need of aggressive monitoring andtherapy to prevent the development of cervical cancer.

A study of pregnancy related acute kidney injury and its outcome at a tertiary care centre, civil hospital, Ahmadabad, Gujarat, India

Background: Pregnancy related acute kidney injury (PRAKI) is acute kidney injury occurring during pregnancy, labour, delivery, and/or postpartum period. Proper management of PRAKI is challenging because (i) both maternal and fetal health must be considered and (ii) the cardiovascular and renal adaptations of pregnancy add to the complexity of diagnosis and management. A multi discipilinary team is often needed to optimize all aspects of the pregnant women’s care.Methods: To study association and contributing factors in pregnancy related Acute Kidney injury, a retrospective study of 39 cases of acute kidney injury complicating pregnancies was carried out in department of obstetrics and gynaecology, B. J. Medical college over a period of 6 months, and results were studied and analysed. Etiological-factors, associated liver pathology, coagulation abnormality, thrombocytopenia, sepsis, recovery status and fetomaternal outcome were studied and results were tabulated. AKI was analysed in terms of maximal stage of renal injury attained as per risk, injury, failure, loss of function, and end-stage renal disease (RIFLE) criteria.Results: The incidence of ARF in pregnancy was found to be 0.3%. Hypertension and its related complications were the most common causative factor. 59.5% of cases required hemodialysis and except for 6 cases (14.3%) all had complete or at least partial recovery from failure.Conclusions: AKI complicating pregnancies are not uncommon in tertiary care centres. If recognized and treated promptly, recovery is assured in majority of 85.7% of cases. Early identification and prompt management of pre-eclampsia and sepsis can prevent majority of ARF cases.

A comparative study of intra-cervical foley’s catheter and PGE2 gel for induction of labour at term

Background: In cervical ripening, before induction of labour, is needed to increase the success of labour induction, to reduce complications and to diminish the rate of caesarean section and duration of labour. Pharmacological preparations are in widespread use for cervical ripening but are not free from side-effects and complications. Mechanical methods, i.e. the use of Foley’s catheter balloon, though effective have not gained much popularity because of the fear of infection. Therefore, the study has been conducted to prove the efficacy and safety of extra amniotic Foley catheter balloon and to compare it with intra-cervical prostaglandin E2 (PGE2) gel. The objective of the study was to the success of induction of labor depends on the cervical status at the time of induction. For effective cervical ripening both Foley's catheter and PGE2 gel are used. The aim of this study was to compare the efficacy of intra cervical Foley's catheter and intra cervical PGE2 gel in cervical ripening for the successful induction of labor.Methods: A randomized, comparative study was conducted in the department of obstetrics and gynaecology, Civil hospital, B.J. Medical College Ahmedabad, during a period of 8 month from September 2018 to April 2019. 100 patients at term with a Bishop's score ≤5 with various indications for induction were randomly allocated to group F (intra-cervical Foley’s catheter) and group P (PGE2 gel) with 50 women included in each group.Results: The groups were comparable with respect to maternal age, gestation age, indication of induction and initial Bishop's score. Both the groups showed significant change in the Bishop's score, 5.10±1.55 and 5.14±1.60 for Foley's catheter and PGE2 gel, respectively, p <0.001. However there was no significant difference between the two groups. There was no significant difference in the side effects and caesarean section rate in both groups. The induction to delivery interval was 16.01±5.50 hours in group F and 16.85 ± 3.81 hours in group P (p=0.073). Apgar scores, birth weights and NICU admissions showed no significant difference between the two groups.Conclusions: The study shows that both Foley's catheter and PGE2 gel are equally effective in pre induction cervical ripening.

Antioxidant And Antimicrobial Activity Of Different Plant Parts Of Anacardium Occidentale L. And Mangifera Indica L.: A Comparative Study

Anacardium occidentale L. and Mangifera indica L. has been used worldwide both for pharmaceutical, food and cosmetic industries due to the presence of biological activities of some of its metabolites. The present study comprises the correlation of antioxidant activity and antimicrobial activity in ethyl acetate extract of young leaves and bark of A. occidentale and M. indica. The activity of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) on radical scavenging effect of the extracts was carried out by spectrophotometrically. All the plant extracts showed DPPH radical scavenging activity and among the extracts, A. occidentale young leaves indicated higher antioxidant potential in comparison with those of the other extracts. The antibacterial activity of various extracts was also screened against some human pathogens of clinical importance; Pseudomonas aeruginosa; Salmonella typhi; Bacillus subtilis; Escherichia coli and Staphylococcus aureus.

Reaction Time and Academic Performance: An Association to Determine The Cognitive Status of First Year Medical Students

Background: Reaction time a pshychomotor test is widelyused in cognitive neuroscience. cognitive functions of humanbrain includes eg. attention, perception, memory, intelligencyetc., all these affect the academics performance, learning,mental processing and motor performance. Reaction time asimple test can measures the time of mental informationprocessing and motor response to it .The mental processingtime is a main factor to affect the academics performance.Aim: To find the relation between audio-visual reaction timeand academic performance for assessing the cognitive statusof first year medical students.Materials and Methods: A cross-sectional study wasconducted in the Department of Physiology, RUHS College ofMedical Sciences, Jaipur from January 2018 to March 2018. Atotal of 64 first year MBBS healthy medical students of agegroup 18-20 years were enrolled in this study (males-36,females-28). The test was performed on Audio Visual ReactionTime (AVRT) machine of Medisystems by pressing the switchas soon as she/he saw the light for VRT or heard the sound forART. Measurement of academic performance was assessedby their performance in the first MBBS university exam.Students with a history of hearing or visual disorder wereexcluded from the study. The Reaction time for both visual andauditory and academic performance was compared betweenthe two groups and correlated the audio-visual reaction timewith the academic performance in both male and females.Statistical analysis was performed using SPSS softwareversion 20.Results: The VRT is (0.71ms) faster than ART (1.63ms). TheRT was not significantly difference in males when compared tofemales and academic performance was significantly more infemales 393.11±40.93 compared to male 368.56±28.87 withp=0.003 and there was a non-significant, weak negativecorrelation of the RT with the academic performance with VRT(r = −0.040, P = 0.75) and ART (r = −0.071, P = 0.57).Conclusion: The RT is shorter in students with high academicperformance and longer in students with low academicperformance.

Effect Of Formalin On C Reactive Protein And Pulmonary Function Tests In Undergraduate Medical Students In Anatomy Dissection Laboratory

Introduction: Formalin is the commonest fixative chemical used for preserving cadavers by embalming andother biological specimens which is commonly used in Medical colleges in Anatomy Dissection hall. C reactiveProtein is an annular pentameric protein found in blood plasma. CRP is synthesised by the liver and itsconcentration increases rapidly during inflammatory processes. The aim of the present study is to reveal thecorrelation between exposure to formalin and changes in pulmonary function tests in undergraduate medicalstudents and to find out the correlation between exposure to formalin and C reactive protein.Materials and Methods: The study was conducted on eighty (40 girls and 40 boys) first year undergraduatemedical students of both the gender between 18-22 years of age in Department of Anatomy and Physiology, ACSMedical college, Chennai. Pulmonary function tests was carried out by Computerised Spirometer before andafter two hours exposure to formalin in the Anatomy dissection hall. Blood sample for serum CRP level estimationwas also taken.Results: There is decrease in values of FVC, FEV1, FEV1/FVC, PEFR and FEF25-75 after 2 hours exposure to formalin.There is decrease in values of FVC, FEV1, FEV1/FVC, PEFR and FEF25-75 in the male participants after 2 hoursexposure to formalin and the only parameter which is statistically significant is PEFR in the female participantsafter exposure to formalin. The values of FEV1 and FEV1/FVC are statistically significant in male and femaleparticipants before exposure to formalin. The values of FEV1/FVC, PEFR and FEF25-75 are statistically significantin male and female participants after exposure to formalin. About 64 students have CRP range of 10.1-40.0mg/l (80%). About 4 students have more increased levels of CRP within the range of 40.1-80.0 mg/l (5%).Conclusion: There is great impact of formalin on CRP and Pulmonary function tests in first year undergraduatemedical students who are constantly exposed to formalin in Anatomy dissection laboratory. To avoid this, eitherprotective measures or alternative measures should be taken.

A study of fetomaternal outcome of hepatic disorders in pregnancy

Background: Liver is a vital organ to maintain physiology of the body and supports every organ of the body. Its proper functioning during pregnancy is essential for a good maternal and fetal outcome. The study analyses the causes and fetomaternal outcome in pregnancies with jaundice and suggests measures to reduce morbidity and mortality.Methods: This is a one-year prospective study in a tertiary care institute during which 7165 deliveries are conducted. Total 55 cases of Jaundice with pregnancy are identified and studied for clinical, biochemical profile, etiology and maternal and fetal outcome. 8 maternal deaths are reported amongst this study group.Results: In this study 55 cases of hepatic disorders in pregnancy are studied. The age group reported is 21-29 years. Majority 72% cases belong to rural areas and 85% in lower socioeconomic class. 96.3% patients were in the third trimester of pregnancy. Most common etiology of hepatic disorders in pregnancy is acute viral hepatitis followed by intrahepatic cholestasis of  pregnancy and preeclampsia and HELLP syndrome. In acute viral hepatitis 81% patients were hepatitis E positive. Most common complication are DIC followed by hemorrhagic shock and subsequently AKI and septicemia. 77.7% babies were born alive and 30.9% NICU admission due to severe birth asphyxia and prematurity. Of these 16.6% died in neonatal period. Maternal mortality in 14.5% patients due to viral hepatits, HELLP and septicemia.Conclusions: Jaundice in pregnancy is a rare medical disorder and deadly combination affecting maternal and fetal outcome. Earl detection and timely intervention with multidisciplinary approach including obstetrician, neonatologist, intensivist and skilled nursing care can help to reduce maternal mortality and morbidity.